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This does not translate directly into human dose equivalence, but it raises serious concerns about attempts to substitute doses.\n\n2. *UNKNOWN EFFECTS ON TOLERANCE*\n\nThe research supporting interest in SR-17018 for opioid tolerance cannot simply be transferred to SHR9352.\n\n3. *UNKNOWN HUMAN SAFETY PROFILE*\n\nThere is insufficient clinical evidence to establish SHR9352's safety, duration of action, or appropriate human dosing. G-protein bias does NOT guarantee protection against respiratory depression.\n\n4. *MISLEADING MARKETING*\n\nA vendor claiming that SHR9352 is equivalent to SR-17018, can replace it in existing protocols, or offers the same withdrawal-related benefits should be asked to provide credible scientific evidence.\n\n⚠️ **ADDITIONAL WARNING: ADDICTION AND INTOXICATION POTENTIAL**\n\nSHR9352 is a highly potent experimental μ-opioid receptor agonist.\n\nThis is important because activation of μ-opioid receptors is associated with drug reward, physical dependence, and addiction.\n\nBeing a G-protein-biased opioid does NOT mean a compound is nonaddictive, nonintoxicating, or incapable of causing respiratory depression.\n\nAlthough SHR9352's human abuse liability has not been adequately characterized, its pharmacology raises legitimate concerns about euphoria, reinforcement, dependence, and overdose.\n\nThere is no scientific basis for assuring consumers that SHR9352 is addiction-free or that it shares SR-17018's experimental tolerance-related properties.\n\nFor individuals attempting to overcome opioid dependence, replacing one experimental opioid with another that has an uncharacterized addiction and withdrawal profile presents serious risks.\n\n**OUR MESSAGE TO THE COMMUNITY**\n\nDO NOT assume SHR9352 is a substitute for SR-17018.\n\nDO NOT apply SR-17018 dosing or taper protocols to SHR9352.\n\nDO NOT interpret the term \"G-protein-biased agonist\" as proof that a compound is safe or produces the same effects as another compound.\n\nAnyone exposed to an experimental opioid should recognize the possibility of respiratory depression and overdose. 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